Serial diffusion MRI to monitor and model treatment response of the targeted nanotherapy

نویسندگان

  • Thomas S.C. Ng
  • David Wert
  • Hargun Sohi
  • Daniel Procissi
  • David Colcher
  • Andrew A. Raubitschek
  • Russell E. Jacobs
چکیده

Title Serial diffusion MRI to monitor and model treatment response of the targeted nanotherapy CRLX101 Authors Thomas S.C. Ng, David Wert, Hargun Sohi, Daniel Procissi, David Colcher, Andrew A. Raubitschek, Russell E. Jacobs 1 Biological Imaging Center, Beckman Institute, California Institute of Technology, Pasadena, California, USA. 2 Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA. 3 Department of Cancer Immunotherapeutics & Tumor Immunology, Beckman Research Institute at City of Hope, Duarte, California, USA.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Serial diffusion MRI to monitor and model treatment response of the targeted nanotherapy CRLX101.

PURPOSE Targeted nanotherapies are being developed to improve tumor drug delivery and enhance therapeutic response. Techniques that can predict response will facilitate clinical translation and may help define optimal treatment strategies. We evaluated the efficacy of diffusion-weighted magnetic resonance imaging to monitor early response to CRLX101 (a cyclodextrin-based polymer particle contai...

متن کامل

Imaging, Diagnosis, Prognosis Serial Diffusion MRI to Monitor and Model Treatment Response of the Targeted Nanotherapy CRLX101

Purpose: Targeted nanotherapies are being developed to improve tumor drug delivery and enhance therapeutic response. Techniques that can predict response will facilitate clinical translation and may help define optimal treatment strategies. We evaluated the efficacy of diffusion-weighted magnetic resonance imaging tomonitor early response to CRLX101 (a cyclodextrin-based polymer particle contai...

متن کامل

Gold nano-popcorn-based targeted diagnosis, nanotherapy treatment, and in situ monitoring of photothermal therapy response of prostate cancer cells using surface-enhanced Raman spectroscopy.

Prostate cancer is the second leading cause of cancer-related death among the American male population, and the cost of treating prostate cancer patients is about $10 billion/year in the United States. Current treatments are mostly ineffective against advanced-stage prostate cancer and are often associated with severe side effects. Driven by these factors, we report a multifunctional, nanotechn...

متن کامل

Role of Apparent diffusion coefficient value in Diffusion Weighted imaging of MRI to assessment of radiotherapy efficiency in the patient with glioma tumor during treatment

Introduction: Glioma is the most common primary malignancy of cerebral neoplasms in adults, which in spite of therapeutic significant efforts, has a very poor prognosis. The current standard treatment of these patients generally includes surgery and radiotherapy or concurrent chemoradiotherapy with 6 courses of adjuvant use of temozolomide tabs. During these years, the nervous...

متن کامل

Gold Nanotechnology for Targeted Diagnosis, Nanotherapy Treatment and In-situ Monitoring of Photothermal Therapy Response of Cancer Cells and Drug Resistance Bacteria

Cancer and multiple drug resistance bacteria (MDRB) remain the greatest challenges in public health care in today’s world. Prostate cancer is the most common malignancy among American men and it is the second leading cause of cancer-related death among the American male population and cost of treating prostate cancer patients can be $10 billion/year in the US. On the other hand, breast cancer i...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013